COVID-19 LED Phototherapy

Coronavirus COVID-19 LED Phototherapy

NEWS: On Tuesday, March 24, 2020, a Philadelphia area foundation committed $12,000 to this COVID-19 LED Phototherapy initiative, and it will serve as an excellent CHALLENGE GRANT for other donations.  

The funding goes to our collaboration partner QuietMIND Foundation, which is a registered 501(c)(3) charitable not-for-profit organization founded in 2000. Every dollar helps! Please donate on this page: https://www.quietmindfdn.org/ 

03.16.2020 Press Release for Coronavirus COVID-19 LED Phototherapy.

For Coronavirus, Pennsylvania’s Independence LED Lighting and QuietMIND Foundation fast-track solutions for nasal and full body infrared (IR) LED photobiomodulation to stop the progression of COVID-19

FOR IMMEDIATE RELEASE

Berwyn, PA, March 16, 2020 – Independence LED Lighting (https://independenceled.com/) announces today its collaboration with the QuietMIND Foundation (https://www.quietmindfdn.org/), a public non-profit applied research foundation and outpatient healthcare practice to fast track development of low-cost, self-administered and easily deployed infrared (IR) phototherapy devices to enhance the immune system’s ability to stop the progress of COVID-19.

The proposed photobiomodulation (PBM) solutions will be rooted in research showing the ability of infrared (IR) light wavelengths to be configured to slow the influenza virus and thereby diminish symptom severity.  The “COVID-19 LED Phototherapy” is intended to boost immune system functioning for those who’ve already contracted COVID-19 while also developing methods to prevent the spread of infection. The effort is focused on fast-tracking basic science and applied clinical trials of devices that are safe, non-invasive and easily deployed for home-use. Such efforts would be running parallel to ongoing acute care and vaccine trials. The COVID-19 LED Phototherapy does not in any way reduce the need for the American public to practice currently recommended social distancing and isolation when necessary during this pandemic.  COVID-19 LED Phototherapy differs from other available low level PBM devices, in that, the wavelength and other delivery parameters for this development are likely to focus on wavelengths above 800nm.  The development team will collaborate closely with manufacturers and PBM researchers to optimize rapid scalable production and broad therapeutic impact.

COVID-19 LED Phototherapy – Patient treatment

Therapy can be administered via one or more of the following:

  • Nasal insert devices
  • Full body horizontal “beds” similar to tanning beds
  • Full body “walk-in” chambers like those now used in gyms and spas.

COVID-19 LED Clinical Phototherapy – Research and Development

The R&D effort will address optimization of phototherapy delivery in terms of:

  1. Wavelength(s)
  2. Power
  3. Irradiance
  4. Pulse rate/width
  5. Dose response
  6. Energy
  7. Fluence
  8. Form factors for optimal treatment delivery, sustainability, and mass production/distribution.

For surface cleaning at all treatment locations, as well as homes and businesses so people can safely return to work, the development team will work to define the most cost-effective hand-held wands using ultraviolet (UV) LED light for sterilization as means to control viral contamination.

COVID-19 LED Phototherapy – Intellectual Property

The development team has agreed to open-source the COVID-19 LED Phototherapy technology and partner with local and global LED manufacturers and relevant supply chain partners during the pandemic to reduce the increase of infections and limit casualties and long-term disability due to compromised pulmonary, cardiovascular and neurological functions. Independence LED Lighting’s CEO, is also the 2020 Chairman of the Leadership Council of the American LED Alliance (https://americanledalliance.com/), which will help serve as a catalyst to provide product specifications and increase the roll-out of these phototherapy technologies.

COVID-19 LED Phototherapy – Fast-track Funding

This initiative requires global, multi-site R&D and testing over the next weeks and through the month of April to help slow the infections and casualties of the pandemic.  The development team is actively seeking $250,000, and the roll-out will then require added funding, which is expected to include joint public-private partnerships with organizations such as Centers for Disease Control and Prevention (CDC), National Health Service and WHO.

“This is an all hands on deck effort. Since 2010, when we moved our LED manufacturing from Shenzhen, China to southeastern Pennsylvania we have focused on a range of LED applications including installations for Walter Reed National Military Medical Center, US Navy hospital ships, the Department of Veterans Affairs (VA) Durham Medical Center, and private sector accounts like Thomas Jefferson University Hospital. We have also pioneered custom wavelength LEDs for advanced Photosynthetic Photon Flux Density (PPFD) for plant science. Now, we can apply our skills and focus to saving lives and positively affecting the growing economic crisis during this Coronavirus pandemic,” said Charlie Szoradi, CEO Independence LED Lighting

“We are now facing an unprecedented health challenge. Our focus has been on integrating light therapy and neuroscience to identify specific properties of light and noninvasive methods to improve central nervous system activity that will enhance immune system functioning. We’re forging strategic relationships with local companies and academic research institutions in Philadelphia, United Kingdom, and Canada to expedite R&D and fast track roll-out of safe, reliable, low-cost, self-administered therapies.” said Marvin Berman, President, QuietMIND Foundation.

Contacts:

Charlie Szoradi, CEO, Independence LED Lighting
Direct: 610-551-5224, Charlie@IndependenceLED.com

Marvin Berman, President, QuietMIND Foundation
Direct: 610-940-0488, info@Quietmindfdn.org

COVID-19 LED Phototherapy – SUPPORT SCIENCE

The right type of phototherapy can help fight COVID-19:

COVID-19 LED Phototherapy: Prevents disease by boosting the immune system

Red light therapy can boost the immune system via hormesis. Hormesis is exposure to low dosages of a harmful substance or other otherwise damaging factors so that an organism or a cell goes through a process of habituation and adapts to it.

With red light therapy, hormesis means that red and near-red light is beamed into cells, which causes mild metabolic stress. This mini-stress results in cells engaging their anti-inflammatory and antioxidant response. In that way, the organism is ready to respond quickly in case of coming in contact with viruses and other types of infections. Infrared is able to penetrate human skin at deeper levels than other wavelengths.

COVID-19 LED Phototherapy

COVID-19 LED Phototherapy: Increase Nitric oxide (NO) production that inhibits viruses

Nitric oxide (NO) is a key signaling molecule between cells, and it has been shown to have an inhibitory effect on some virus infections. Antimicrobial activity of NO has been described for several bacteria and for some viruses, including Coronaviruses.

Center for Microbiological Preparedness, Stockholm, Sweden conducted research that showed that NO prevents SARS CoV from replication. SARS CoV is very similar virus to nCoV. NO has the power to inhibit the synthesis of the RNA and stops the virus from spreading. Red light therapy comes to play by boosting the production of NO. This is one of the commonly well-known effects red light therapy has on the body.

COVID-19 LED Phototherapy: Prevents the development of severe lung inflammation

Research – Low-Level Laser Therapy Reduces Lung Inflammation in an Experimental Model of Chronic Obstructive Pulmonary Disease Involving P2X7 Receptor. The research has shown that exposure to LLLT seriously reduced the number of inflammatory cells. It has been recorded that red light therapy shows promising results in regulating the pro-inflammatory cytokine levels.

Collagen deposition is another important factor to consider when dealing with lung inflammation. Collagen deposition in the lungs can happen even with severe influenza infections. Red light therapy is an excellent means to regulate collagen production, decreasing this sort of deposition and reducing the effects of lung inflammation. RLT also reduces inflammation and promotes tissue regeneration. Placing the phototherapy device close to or on the skin increases the level of penetration.

COVID-19 LED Phototherapy

COVID-19 LED Phototherapy: Inactivates the virus by affecting its ability to infect the host cells

A team of Chinese scientists studied the mechanism of low-intensity laser irradiation effects on virus. They focus on the fact that Coronavirus has several important proteins, three of which are building blocks of its ‘envelope’.

One of those four proteins are spikes that play an important role in connecting and infecting the host cells. They have their part in inactivating the cell antibodies and even the infection process itself.  This spike protein is found on the surface of the virus and it is also photosensitive. These two properties make it a great target for red light therapy devices. A red light could aim the spike proteins, making the infection of the host cells difficult or even impossible for the virus.

Added benefits of COVID 19 LED Phototherapy: High nanometer infrared has a positive impact on the human brain

Transcranial Photobiomodulation (tPBM) with 1,065-nm Laser to improve cerebral metabolism of the Human Brian in Viro. This study provided strong evidence to validate/confirm previous findings that tPBM with 1,064‐nm laser enables to increase cerebral ∆[HbO] and ∆[oxi‐CCO] in the human brain, as measured by bb‐NIRS. Overall, it demonstrated the robust reproducibility of tPBM being able to improve cerebral hemodynamics and metabolism of the human brain in vivo in both young and older adults.

COVID-19 LED Phototherapy

Advantages of infrared over red light therapy:

The underlying systemic issue with viral disorders, especially ones that involve neurodegeneration, are rooted in processes that foster hypoperfusion and inflammation. Photobiomodulation (PBM) has been shown to affect both positively. Unlike red light therapy (RLT) the infrared PBM penetrates and helps increase adenosine triphosphate (ATP) and reduce Nitric oxide (NO) along with other factors that mitigate against apoptosis. 

Hypoperfusion is a term that describes “a reduced amount of blood flow”. When ischemia develops due to low blood flow, we may describe this as “hypoperfusion“. Causes for hypoperfusion include low blood pressure, heart failure or loss of blood volume. Ischemia can affect any organ of the body

ATP is a phosphorylated nucleotide C10H16N5O13P3 composed of adenosine and three phosphate groups that supplies energy for many biochemical cellular processes by undergoing enzymatic hydrolysis especially to ADP. — called also adenosine triphosphate

 

 

COVID-19 LED Phototherapy

140 Yorktown Plaza Elkins Park PA 19027 610-940-0488 www.quietmindfdn.org

NEW: March 28, 2020

Pilot Trial Evaluating Efficacy of Photobiomodulation as Rapid COVID-19 Treatment

This is proprietary information. Please Contact Us for more information, subject to recipient review on a case-by-case basis per via Non-Disclosure Agreement.